Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon
Identifieur interne : 003B81 ( Main/Exploration ); précédent : 003B80; suivant : 003B82Control of coronavirus infection through plasmacytoid dendritic-cell-derived type I interferon
Auteurs : Luisa Cervantes Barragan [Suisse, Mexique] ; Roland Zust [Suisse] ; Friedemann Weber [Allemagne] ; Martin Spiegel [Allemagne] ; Karl S. Lang [Suisse] ; Shizuo Akira [Japon] ; Volker Thiel [Suisse] ; Burkhard Ludewig [Suisse]Source :
- Blood [ 0006-4971 ] ; 2007.
Descripteurs français
- KwdFr :
- Animaux, Cellules dendritiques (immunologie), Cellules dendritiques (métabolisme), Glycoprotéines membranaires (immunologie), Humains, Infections à coronavirus (immunologie), Infections à coronavirus (virologie), Infections à coronavirus (étiologie), Interféron alpha (biosynthèse), Interféron de type I (biosynthèse), Interféron de type I (immunologie), Récepteur de type Toll-7 (immunologie), Réplication virale, Souris, Virus du SRAS.
- MESH :
- biosynthèse : Interféron alpha, Interféron de type I.
- immunologie : Cellules dendritiques, Glycoprotéines membranaires, Infections à coronavirus, Interféron de type I, Récepteur de type Toll-7.
- métabolisme : Cellules dendritiques.
- virologie : Infections à coronavirus.
- étiologie : Infections à coronavirus.
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Alpha interferon, Animals, Beta interferon, Coronavirus, Coronavirus Infections (etiology), Coronavirus Infections (immunology), Coronavirus Infections (virology), Dendritic Cells (immunology), Dendritic Cells (metabolism), Dendritic cell, Human, Humans, Infection, Interferon Type I (biosynthesis), Interferon Type I (immunology), Interferon-alpha (biosynthesis), Membrane Glycoproteins (immunology), Mice, Mouse, Murine hepatitis virus, Plasmacytoid dendritic cell, Primary culture, SARS Virus, Severe acute respiratory syndrome, T cell receptor, Toll-Like Receptor 7 (immunology), Virus Replication.
- MESH :
- chemical , biosynthesis : Interferon Type I, Interferon-alpha.
- etiology : Coronavirus Infections.
- immunology : Coronavirus Infections, Dendritic Cells, Interferon Type I, Membrane Glycoproteins, Toll-Like Receptor 7.
- metabolism : Dendritic Cells.
- virology : Coronavirus Infections.
- Animals, Humans, Mice, SARS Virus, Virus Replication.
Abstract
This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-a production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections.
Affiliations:
- Allemagne, Japon, Mexique, Suisse
- Bade-Wurtemberg, District de Fribourg-en-Brisgau
- Fribourg-en-Brisgau
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Le document en format XML
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aut.</sZ></inist:fA14><country>Mexique</country><wicri:noRegion>Mexico City</wicri:noRegion></affiliation></author><author><name sortKey="Zust, Roland" sort="Zust, Roland" uniqKey="Zust R" first="Roland" last="Zust">Roland Zust</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Research Department, Kantonal Hospital St Gallen</s1><s2>St Gallen</s2><s3>CHE</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>St Gallen</wicri:noRegion></affiliation></author><author><name sortKey="Weber, Friedemann" sort="Weber, Friedemann" uniqKey="Weber F" first="Friedemann" last="Weber">Friedemann Weber</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg</s1><s2>Freiburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Spiegel, Martin" sort="Spiegel, Martin" uniqKey="Spiegel M" first="Martin" last="Spiegel">Martin Spiegel</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Abteilung Virologie, Institut fur Medizinische Mikrobiologie und Hygiene, Universitat Freiburg</s1><s2>Freiburg</s2><s3>DEU</s3><sZ>3 aut.</sZ><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Lang, Karl S" sort="Lang, Karl S" uniqKey="Lang K" first="Karl S." last="Lang">Karl S. Lang</name><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Institute of Experimental Immunology, University Hospital</s1><s2>Zurich</s2><s3>CHE</s3><sZ>5 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Akira, Shizuo" sort="Akira, Shizuo" uniqKey="Akira S" first="Shizuo" last="Akira">Shizuo Akira</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Host Defense, Osaka University</s1><s2>Osaka</s2><s3>JPN</s3><sZ>6 aut.</sZ></inist:fA14><country>Japon</country><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Research Department, Kantonal Hospital St Gallen</s1><s2>St Gallen</s2><s3>CHE</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>St Gallen</wicri:noRegion></affiliation></author><author><name sortKey="Ludewig, Burkhard" sort="Ludewig, Burkhard" uniqKey="Ludewig B" first="Burkhard" last="Ludewig">Burkhard Ludewig</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Research Department, Kantonal Hospital St Gallen</s1><s2>St Gallen</s2><s3>CHE</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>7 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>Suisse</country><wicri:noRegion>St Gallen</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">Blood</title><title level="j" type="abbreviated">Blood</title><idno type="ISSN">0006-4971</idno><imprint><date when="2007">2007</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Blood</title><title level="j" type="abbreviated">Blood</title><idno type="ISSN">0006-4971</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alpha interferon</term><term>Animals</term><term>Beta interferon</term><term>Coronavirus</term><term>Coronavirus Infections (etiology)</term><term>Coronavirus Infections (immunology)</term><term>Coronavirus Infections (virology)</term><term>Dendritic Cells (immunology)</term><term>Dendritic Cells (metabolism)</term><term>Dendritic cell</term><term>Human</term><term>Humans</term><term>Infection</term><term>Interferon Type I (biosynthesis)</term><term>Interferon Type I (immunology)</term><term>Interferon-alpha (biosynthesis)</term><term>Membrane Glycoproteins (immunology)</term><term>Mice</term><term>Mouse</term><term>Murine hepatitis virus</term><term>Plasmacytoid dendritic cell</term><term>Primary culture</term><term>SARS Virus</term><term>Severe acute respiratory syndrome</term><term>T cell receptor</term><term>Toll-Like Receptor 7 (immunology)</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term><term>Cellules dendritiques (immunologie)</term><term>Cellules dendritiques (métabolisme)</term><term>Glycoprotéines membranaires (immunologie)</term><term>Humains</term><term>Infections à coronavirus (immunologie)</term><term>Infections à coronavirus (virologie)</term><term>Infections à coronavirus (étiologie)</term><term>Interféron alpha (biosynthèse)</term><term>Interféron de type I (biosynthèse)</term><term>Interféron de type I (immunologie)</term><term>Récepteur de type Toll-7 (immunologie)</term><term>Réplication virale</term><term>Souris</term><term>Virus du SRAS</term></keywords><keywords scheme="MESH" type="chemical" qualifier="biosynthesis" xml:lang="en"><term>Interferon Type I</term><term>Interferon-alpha</term></keywords><keywords scheme="MESH" qualifier="biosynthèse" xml:lang="fr"><term>Interféron alpha</term><term>Interféron de type I</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Cellules dendritiques</term><term>Glycoprotéines membranaires</term><term>Infections à coronavirus</term><term>Interféron de type I</term><term>Récepteur de type Toll-7</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Coronavirus Infections</term><term>Dendritic Cells</term><term>Interferon Type I</term><term>Membrane Glycoproteins</term><term>Toll-Like Receptor 7</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Dendritic Cells</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cellules dendritiques</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term></keywords><keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Mice</term><term>SARS Virus</term><term>Virus Replication</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Infection</term><term>Coronavirus</term><term>Cellule dendritique</term><term>Réplication virale</term><term>Souris</term><term>Syndrome respiratoire aigu sévère</term><term>Récepteur cellule T</term><term>Virus du SRAS</term><term>Virus hépatite murine</term><term>Interféron alpha</term><term>Interféron bêta</term><term>Souris</term><term>Homme</term><term>Culture primaire</term><term>Cellule dendritique plasmocytoïde</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study demonstrates a unique and crucial role of plasmacytoid dendritic cells (pDCs) and pDC-derived type I interferons (IFNs) in the pathogenesis of mouse coronavirus infection. pDCs controlled the fast replicating mouse hepatitis virus (MHV) through the immediate production of type I IFNs. Recognition of MHV by pDCs was mediated via TLR7 ensuring a swift IFN-a production following encounter with this cytopathic RNA virus. Furthermore, the particular type I IFN response pattern was not restricted to the murine coronavirus, but was also found in infection with the highly cytopathic human severe acute respiratory syndrome (SARS) coronavirus. Taken together, our results suggest that rapid production of type I IFNs by pDCs is essential for the control of potentially lethal coronavirus infections.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Japon</li><li>Mexique</li><li>Suisse</li></country><region><li>Bade-Wurtemberg</li><li>District de Fribourg-en-Brisgau</li></region><settlement><li>Fribourg-en-Brisgau</li></settlement></list><tree><country name="Suisse"><noRegion><name sortKey="Cervantes Barragan, Luisa" sort="Cervantes Barragan, Luisa" uniqKey="Cervantes Barragan L" first="Luisa" last="Cervantes Barragan">Luisa Cervantes Barragan</name></noRegion><name sortKey="Lang, Karl S" sort="Lang, Karl S" uniqKey="Lang K" first="Karl S." last="Lang">Karl S. Lang</name><name sortKey="Ludewig, Burkhard" sort="Ludewig, Burkhard" uniqKey="Ludewig B" first="Burkhard" last="Ludewig">Burkhard Ludewig</name><name sortKey="Thiel, Volker" sort="Thiel, Volker" uniqKey="Thiel V" first="Volker" last="Thiel">Volker Thiel</name><name sortKey="Zust, Roland" sort="Zust, Roland" uniqKey="Zust R" first="Roland" last="Zust">Roland Zust</name></country><country name="Mexique"><noRegion><name sortKey="Cervantes Barragan, Luisa" sort="Cervantes Barragan, Luisa" uniqKey="Cervantes Barragan L" first="Luisa" last="Cervantes Barragan">Luisa Cervantes Barragan</name></noRegion></country><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Weber, Friedemann" sort="Weber, Friedemann" uniqKey="Weber F" first="Friedemann" last="Weber">Friedemann Weber</name></region><name sortKey="Spiegel, Martin" sort="Spiegel, Martin" uniqKey="Spiegel M" first="Martin" last="Spiegel">Martin Spiegel</name></country><country name="Japon"><noRegion><name sortKey="Akira, Shizuo" sort="Akira, Shizuo" uniqKey="Akira S" first="Shizuo" last="Akira">Shizuo Akira</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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